LASSI-L in Middle Age Children of Late-onset AD Patients
LASSI-L in Middle Age Children of Late-onset AD Patients
Brain Structural and Amyloid Correlates of Recovery from Semantic Interference in Cognitively Normal Individuals with or without family History of Late-Onset Alzheimer’s Disease.
Abulafia et. al J Neuropsychiatry Clin Neurosci. (2019)
Journal of Neuropsychiatry and Clinical Neuroscience
Brain Structural and Amyloid Correlates of Recovery From Semantic Interference in Cognitively Normal Individuals With or Without Family History of Late-Onset Alzheimer's Disease
SUMMARY
Failure to recover from proactive semantic interference (frPSI) has been shown to be more sensitive than traditional cognitive measures in different populations with preclinical Alzheimer’s disease. The authors sought to characterize the structural and amyloid in vivo correlates of frPSI in cognitively normal offspring of patients with late-onset Alzheimer’s disease (O-LOAD), compared with individuals without a family history of neurodegenerative disorders (CS).
Recovery from proactive semantic interference (frPSI) and RAVLT delayed recall were lower in O-LOAD cases. Better recovery from retroactive semantic interference was associated with less amyloid load in the left temporal lobe in O-LOAD but not CS. In middle-aged cognitively normal individuals with one parent affected with LOAD, frPSI was impaired compared with persons without a family history of LOAD.
