LASSI-L in Diverse Cultural Populations
LASSI-L in Diverse Cultural Populations
A Cognitive Stress Test for prodromal Alzheimer’s disease: Multi-ethnic generalizability.
Curiel et. al Alzheimer’s Dement (Amst) (2019)
Alzheimer’s & Dementia
A cognitive stress test for prodromal Alzheimer's disease: Multiethnic generalizability
SUMMARY
Culturally fair cognitive assessments sensitive to detecting changes associated with prodromal Alzheimer’s disease are needed. Performance of Hispanic and non-Hispanic older adults on the Loewenstein-Acevedo Scale of Semantic Interference and Learning (LASSI-L) was examined in persons with amnestic mild cognitive impairment (aMCI) or normal cognition. The association between a novel cognitive marker, the failure to recover from proactive semantic interference (frPSI), and cortical thinning was explored.
In diverse populations, LASSI-L performance differentiated patients with aMCI from cognitively normal older adults and was associated with thinning in Alzheimer’s disease-prone regions, suggesting its clinical utility.
