LASSI-L as a Screening Instrument
LASSI-L as a Screening Instrument
Unraveling progressive verbal memory deficits in Huntington’s disease: insights from the LASSI-L
Sierra Luis A. et al., Frontiers in Neurology (2025)
Frontiers in Neurology
Unraveling progressive verbal memory deficits in Huntington’s disease: insights from the LASSI-L
SUMMARY
Huntington’s disease (HD) is characterized by progressive cognitive decline, with early deficits often preceding motor symptoms. The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) captures many types of deficits in verbal memory including susceptibility to interference. The current study aims to delineate the progression of these deficits across different stages of HD.
The LASSI-L appears to be a useful tool for detecting early and progressive cognitive changes in Huntington’s disease, particularly by capturing the sequential nature of verbal memory deficits, including early vulnerability to interference. These findings suggest that the LASSI-L may help refine HD staging by integrating sequential neuropsychological markers of cognitive decline.
