LASSI-L as a Screening Instrument
LASSI-L as a Screening Instrument
A Brief Version of the LASSI-L Detects Prodromal Alzheimer’s Disease States.
Crocco et al. Journal of Alzheimer’s Disease (2020)
Journal of Alzheimer’s Disease
A Brief Version of the LASSI-L Detects Prodromal Alzheimer's Disease States
SUMMARY
The Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L) is an increasingly utilized cognitive stress test designed to identify early cognitive changes associated with incipient neurodegenerative disease. The objective was to examine previously derived cut-points for cognitively unimpaired older adults that were suggestive of performance impairment on multiple subscales of the LASSI-L.
Only 7.7% of HC were incorrectly classified as having impairments. A modest number of LASSI-L subscales taking approximately 8 minutes to administer, had excellent discriminative ability using established cut-offs among individuals with presumptive stages of AD. This has potential implications for both clinical practice and clinical research settings targeting AD during early prodromal stages.
