LASSI-L and MRI Markers in PreMCI
LASSI-L and MRI Markers in PreMCI
A Novel Cognitive Assessment Paradigm to Detect Pre-Mild Cognitive Impairment (PreMCI) and the Relationship to Biological Markers of Alzheimer’s Disease.
Crocco et. al Journal of Psychiatric Research (2018)
Journal of Psychiatric Research
A novel cognitive assessment paradigm to detect Pre-mild cognitive impairment (PreMCI) and the relationship to biological markers of Alzheimer's disease
SUMMARY
A number of older adults obtain normal scores on formal cognitive tests, but present clinical concerns that raise suspicion of cognitive decline. Despite not meeting full criteria for Mild Cognitive Impairment (MCI), these PreMCI states confer risk for progression to Alzheimer’s disease (AD). This investigation addressed a pressing need to identify cognitive measures that are sensitive to PreMCI and are associated with brain biomarkers of neurodegeneration.
PreMCI participants evidenced greater LASSI- L deficits, particularly with regards to frPSI and delayed recall, relative to the CN group.
