FUNCTIONAL SKILLS ASSESSMENT
FUNCTIONAL SKILLS ASSESSMENT
Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer’s Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures
Hyun Kim et al., Alzheimer’s and Dementia (2024)
Alzheimer’s and Dementia
Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer’s Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures
SUMMARY
This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early-stage Alzheimer’s disease (AD) clinical trials. Their psychometric properties and associations with AD risk markers were compared to those of well-established measures.
Highlight were that well-established cognitive tests may not accurately detect subtle cognitive changes. No Practice Effect (NPE) and Computerized Functional Skills Assessment and Training are novel measures designed to have improved psychometric properties. Novel measures had better psychometric properties compared to established measures. Significant associations with Alzheimer’s disease biomarkers were found with novel measures.
