Differential Diagnosis – LASSI-L and Amyloid Markers of PreClinical AD
Differential Diagnosis – LASSI-L and Amyloid Markers of PreClinical AD
Utilizing Semantic Intrusions to Identify Amyloid Positivity in Mild Cognitive Impairment.
Loewenstein et. al Neurology (2018)
Neurology
Utilizing semantic intrusions to identify amyloid positivity in mild cognitive impairment
SUMMARY
Semantic intrusion (SI) errors may highlight specific breakdowns in memory associated with preclinical Alzheimer disease (AD); however, there have been no investigations to determine whether SI errors occur with greater frequency in persons with amnestic mild cognitive impairment (aMCI) confirmed as amyloid positive (Amy+) vs those who have clinical symptoms of aMCI-AD with negative amyloid scans (suspected non-AD pathology [SNAP]) or persons who are diagnosed with other brain disorders affecting cognition.
SIs on the LASSI-L related to PSI and frPSI uniquely differentiated Amy+ and Amy- participants with aMCI and likely reflect deficits with inhibition and source memory in preclinical AD not captured by traditional cognitive measures. This may represent a specific, noninvasive test successful at distinguishing cases with true AD from those with SNAP.
