Differential Diagnosis: LASSI-L and amyloid Markers of Mild Cognitive Impairment
Differential Diagnosis: LASSI-L and amyloid Markers of Mild Cognitive Impairment
The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults.
Kitaigorodsky et al. Alzheimers’ and Dementia (2021)
Alzheimers’ and Dementia
The relationship of semantic intrusions to different etiological subtypes of MCI and cognitively healthy older adults
SUMMARY
There is increasing evidence that susceptibility to proactive semantic interference (PSI) and the failure to recover from PSI (frPSI) as evidenced by intrusion errors may be early cognitive markers of both preclinical and prodromal Alzheimer’s disease (AD). One hundred forty-five participants were administered extensive clinical and neuropsychological evaluations including the Loewenstein-Acevedo Scales for Semantic Interference and Learning (LASSI-L), a sensitive cognitive stress test measuring PSI and frPSI. Participants also underwent structural magnetic resonance imaging (MRI) and amyloid positron emission tomography/computed tomography (PET/CT) imaging.
Semantic intrusion errors on the LASSI-L occur much less frequently in persons who have different types of non-AD-related MCI and may be used as an early cognitive marker of prodromal AD.
