Differential Diagnosis – LASSI-L and Amyloid Markers of Mild Cognitive Impairment
Differential Diagnosis – LASSI-L and Amyloid Markers of Mild Cognitive Impairment
Semantic Intrusions and Failure to Recover from Proactive Semantic Interference in Amnestic Mild Cognitive Impairment: Relationship to Amyloid Load and Cortical Thickness.
Curiel et. al Curr Alzheimer Res. (2018)
Current Alzheimer's Research
Intrusions and Failure to Recover From Semantic Interference in Mild Cognitive Impairment: Relationship to Amyloid and Cortical Thickness
SUMMARY
Accumulating evidence indicates that the failure to recover from the effects of proactive semantic interference [frPSI] represents an early cognitive manifestation of preclinical Alzheimer’s disease. A limitation of this novel paradigm has been a singular focus on the number of targets correctly recalled, without examining co-occurring semantic intrusions [SI] that may highlight specific breakdowns in memory. We focused on SI and their relationship to amyloid load and regional cortical thickness among persons with amnestic mild cognitive impairment (aMCI).
Semantic intrusions on measures susceptible to frPSI related to greater brain amyloid load and lower cortical thickness. These findings further support the hypothesis that frPSI, as expressed by the percentage of intrusions, may be a cognitive marker of initial neurodegeneration and may serve as an early and distinguishing test for preclinical AD that may be used in primary care or clinical trial settings.
