Differential Diagnosis – LASSI-L and Amyloid Markers of Mild Cognitive Impairment
Differential Diagnosis – LASSI-L and Amyloid Markers of Mild Cognitive Impairment
A novel method of evaluating semantic intrusion errors to distinguish between amyloid positive and negative groups on the Alzheimer’s disease continuum.
Curiel et. al Journal of Psychiatric Research (2018)
Cognitive and Behavioral Neurology
Using the LASSI-L to Detect Robust Interference Effects in Premanifest Huntington Disease
SUMMARY
Diagnosis of manifest Huntington disease (HD) is based primarily on motor symptoms, but premanifest HD (preHD) is often associated with subtle cognitive decline. Objective of the study was to determine the utility of the LASSI–L for detecting early cognitive decline in individuals with preHD and to compare the results of the LASSI–L with those of commonly used neuropsychological tests in HD.
The study found that LASSI–L is a sensitive instrument for detecting early interference effects in individuals with preHD that outperforms commonly used neuropsychological tests. The LASSI–L could be a useful addition to clinical and research protocols involving individuals with preHD.
