LASSI-L as a Screening Instrument
LASSI-L as a Screening Instrument
LASSI-L detects early cognitive changes in pre-motor manifest Huntington’s disease: a replication and validation study
Sierra Luis A. et al., Frontiers in Neurology (2023)
Frontiers in Neurology
LASSI-L detects early cognitive changes in pre-motor manifest Huntington’s disease: a replication and validation study
SUMMARY
Cognitive decline is an important early sign in premotor manifest Huntington’s disease (preHD) and is characterized by deficits across multiple domains including executive function, psychomotor processing speed, and memory retrieval. Prior work suggested that the Loewenstein-Acevedo Scale for Semantic Interference and Learning (LASSI-L)–a verbal learning task that simultaneously targets these domains – could capture early cognitive changes in preHD. The current study aimed to replicate, validate and further analyze the LASSI-L in preHD using larger datasets.
The study found that LASSI-L is a sensitive, reliable, efficient tool for detecting cognitive decline in preHD.
