Differential Diagnosis – LASSI-L and Amyloid Markers of PreClinical AD
Differential Diagnosis – LASSI-L and Amyloid Markers of PreClinical AD
A Novel Cognitive Stress Test for the Detection of Preclinical Alzheimer’s Disease: Discriminative Properties and relation to Amyloid Load.
Loewenstein et. al American Journal of Geriatric Psychiatry (2016)
Journal of Geriatric Psychiatry
A Novel Cognitive Stress Test for the Detection of Preclinical Alzheimer Disease: Discriminative Properties and Relation to Amyloid Load
SUMMARY
The objective was to examine the utility of a novel “cognitive stress test” to detect subtle cognitive impairments and amyloid load within the brains of neuropsychologically normal community-dwelling elders.
LASSI-L deficits were identified among 89% of those with MCI, 47% with PreMCI, 33% with SMI, and 13% classified as CN. Failure to recover or compensate for the effects of PSI on the LASSI-L distinguishes the LASSI-L from other widely used neuropsychological tests and appears to be sensitive to subtle cognitive impairments and increasing amyloid load.
